Science Magazine


Biological Learning to let go: The extinction of fear memory
Induction of Fear Extinction with Hippocampal-Infralimbic BDNF.  Peters et al.
annotated by Adam Swiercz
Fear learning allows us to identify and evade dangers in the environment.  Associating predictive cues with negative outcomes is critical to the survival of many species. Using Pavlovian conditioning, lab...

annotations posted 10/21/2016
original paper published 06/04/2010

Biological Amyloid and tau: Both may be needed for developing Alzheimer's disease
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model. Roberson et al.
annotated by Hilary Gerstein
Plaques made of amyloid-β and tangles made of abnormal tau proteins are the hallmarks of Alzheimer's disease. Until recently, most of the work exploring what causes these...

annotations posted 10/07/2016
original paper published 05/04/2007

Biological Rats to the rescue
Empathy and Pro-Social Behavior in Rats. Bartal, al.
annotated by Chantal Bodkin-Clarke
Previous studies have shown that nonmammal primates will act to help another in distress. However, attempts to pinpoint the source of motivation behind these helping actions were ambiguous. In this study, rats learned...

annotations posted 10/05/2016
original paper published 12/09/2011

Physical High-throughput screening of drug leads
Nanomole-scale high-throughput chemistry for the synthesis of complex molecules. Santanilla et al.
annotated by Gurshagan Kandhola
In early stages of drug discovery, large quantities of materials are rarely available. The authors in this paper have come up with a miniaturized automation platform enabling...

annotations posted 08/23/2016
original paper published 01/02/2015

Biological CSI Africa: Tracking ivory poachers
Genetic assignment of large seizures of elephant ivory reveals Africa’s major poaching hotspots. Wasser et al.
annotated by Travis Dittmer and Paul Beardsley
The illegal ivory trade threatens the persistence of stable wild African elephant populations. The underground and covert nature of poaching makes it difficult to...

annotations posted 08/18/2016
original paper published 07/03/2015

Biological A caffeine jolt gives bees a buzz to remember
Caffeine in Floral Nectar Enhances a Pollinator's Memory of Reward. Wright et al.
annotated by Tara Bracken
Many compounds produced by plants as a defense against predation are known to have interesting effects on humans. One such drug, caffeine, improves human memory and alertness, lending increased focus and a manic...

annotations posted 08/08/2016
original paper published 03/08/2013

Biological Limb regeneration: fact or (science) fiction?
Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate. Kumar et al.
annotated by Jason Librande
Human limb regeneration has been a common theme throughout fiction. The Amazing Spider-Man makes good use of this idea by telling the story of a scientist who, while trying to...

annotations posted 07/29/2016
original paper published 11/02/2007

Physical Expanding the limits of optical resolution
Expansion microscopy. Chen et al.
annotated by Bob Kao
How do scientists examine organ development and diseases at subcellular resolution? Recent cutting-edge imaging modalities—called superresolution microsopy—enable scientists to examine molecules at nanoscale resolution.  The authors of this article discovered a new...

annotations posted 07/27/2016
original paper published 07/18/2016

Biological Can we handle the power of CRISPR?
The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations. Gantz et al.
annotated by Jennifer Susan Stancill
The CRISPR-Cas9 gene editing system has taken the molecular biology world by storm. Originally discovered in Streptococcus pyogenes as a way for the bacteria to fight off...

annotations posted 07/26/2016
original paper published 04/24/2015

Biological Brain makeover
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors. Katsimpardi et al.
annotated by Eshini Panditharatna
What happens when an old mouse and young mouse are sewn together to create one vascular system?  Scientists were able to identify the influence caused by factors unique to the...

annotations posted 07/22/2016
original paper published 05/09/2014